Microtubules and Neuronal Polarity
نویسندگان
چکیده
منابع مشابه
Microtubules and Neuronal Polarity Lessons from Mitosis
tween a radial array of microtubules during interphase Introduction and a bipolar spindle of microtubules during mitosis. Neurons are the principle signaling cells of the nervous The microtubules are associated with their sites of nusystem. In order to transmit signals, neurons stop dividcleation within the single interphase centrosome or ing early in development and direct their efforts instea...
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Early-onset primary dystonia is an inherited disorder characterized by involuntary twisting, repetitive movements and abnormal postures. It has recently been demonstrated that the DYT1 gene is the most relevant gene associated with primary generalized dystonia. The DYT1 gene product is a 332-aminoacid long protein, termed TorsinA, whose function is still not clear. Based on the results obtained...
متن کاملStructural Polarity of Kinetochore Microtubules
The polarity of kinetochore microtubules (MTs) has been studied in lysed PtK1 cells by polymerizing hook-shapdd sheets of neurotubulin onto the walls of preexisting cellular MTs in a fashion that reveals their structural polarity . Three different approaches are presented here : (a) we have screened the polarity of all MTs in a given spindle cross section taken from the region between the kinet...
متن کاملStructural Polarity of Kinetochore Microtubules
The polarity of kinetochore microtubules (MTs) has been studied in lysed PtK1 cells by polymerizing hook-shapdd sheets of neurotubulin onto the walls of preexisting cellular MTs in a fashion that reveals their structural polarity . Three different approaches are presented here : (a) we have screened the polarity of all MTs in a given spindle cross section taken from the region between the kinet...
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The polarity orientation of cellular microtubules is widely regarded to be important in understanding the control of microtubule assembly and microtubule-based motility in vivo. We have used a modification of the method of Heidemann and McIntosh (Nature (Lond.). 286:517-519) to determine the polarity orientation of axonal microtubules in postganglionic sympathetic fibers of the cat. In fibers f...
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ژورنال
عنوان ژورنال: Neuron
سال: 1999
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80675-3